Modulation of intracellular calcium levels inhibits secretion of collagenase 1 by migrating keratinocytes.

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Modulation of intracellular calcium levels inhibits secretion of collagenase 1 by migrating keratinocytes.

Calcium concentration influences keratinocyte differentiation, and, following injury, keratinocytes move through an environment of changing calcium levels. Because these migrating cells in wounds invariably express collagenase 1, we assessed if modulation of calcium levels regulates collagenase 1 production by primary human keratinocytes. Accurately reflecting the confined spatial pattern of en...

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ژورنال

عنوان ژورنال: Molecular Biology of the Cell

سال: 1997

ISSN: 1059-1524,1939-4586

DOI: 10.1091/mbc.8.5.811